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Helena Florindo




Helena Florindo
Researcher, FFULisboa


Helena F Florindo graduated in Pharmaceutical Sciences in 2003 (University of Lisbon) and obtained her Ph.D. degree in Pharmaceutical Technology in 2008 (University of Lisbon), in collaboration with the University of London. Currently, she is an Assistant Professor at the Faculty of Pharmacy, University of Lisbon. She is the Group Leader of the BioNanoSciences – Drug Delivery & Immunotherapy research group, at the Research Institute for Medicines. Both nanotechnology and immune-oncology fields have motivated her multidisciplinary research focused on the rational development of functionalized nanobiomaterials as novel immunotherapies for cancer treatment. It includes the characterization of the anti-tumor effects induced by the combination of nano-vaccines with nano-therapeutics designed to modulate the functions of key cells within tumor microenvironment, such as T cells, myeloid-derived cells and tumor cells.



"Multivalent nanoparticles to reprogram tumor microenvironment for advanced immunotherapy"

Our research has been focused on the development of nanoparticle-based immunotherapeutic alternative treatments that combine dendritic cell targeting with the immune-modulation of additional key players within tumor microenvironment.  We will show that our cancer nano-vaccines modulate the functionality of multiple tumour-stroma-immune cells towards an effective eradication of these malignant cells, but also a broad effector and memory anti-tumour immune response.


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